MFV3D Book Archive > Nursing > Download 2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th by John S. Bradley MD, John D. Nelson MD Emeritus, Dr. PDF

Download 2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th by John S. Bradley MD, John D. Nelson MD Emeritus, Dr. PDF

By John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Pablo J Sanchez MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach

This bestselling and universal source on pediatric antimicrobial treatment offers speedy entry to trustworthy options for therapy of all infectious illnesses in children.

For each one disorder, the authors offer a observation to assist overall healthiness care prone pick out the easiest of all antimicrobial offerings. The inquiring health professional can instantly hyperlink to the proof for the advice within the publication or cellular model. Drug descriptions conceal all antimicrobial brokers to be had this present day and contain whole information regarding dosing regimens.

In reaction to starting to be matters approximately overuse of antibiotics, the ebook comprises instructions on whilst to not prescribe antimicrobials.

Key good points in nineteenth Edition!

- up to date information about the power and the extent of facts for all remedy innovations

- New bankruptcy on antibiotic treatment for overweight little ones

- New bankruptcy on antimicrobial prophylaxis and prevention of symptomatic an infection

- comprises remedy of parasitic infections and tropical drugs.

- up to date anti-infective drug directory, entire with formulations and dosages.

- Balanced info on security, efficacy and tolerability with facts on expenses and availability of substances

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Additional info for 2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th Edition

Sample text

And clindamycin (BII) S aureus coverage is only fair with amox/clav, ticar/clav, pip/tazo. For penicillin allergy, consider ciprofloxacin (for Pasteurella) plus clindamycin (BIII). 38 — Chapter 6. Antimicrobial Therapy According to Clinical Syndromes A. SKIN AND SOFT TISSUE INFECTIONS Standard: cephalexin 50–75 mg/kg/day PO div tid OR amox/clav 45 mg/kg/day PO div tid (CII) CA-MRSA: clindamycin 30 mg/kg/day PO div tid OR TMP/SMX 8 mg/kg/day of TMP PO div bid; for 5–7 days (CIII) For topical therapy if mild infection: mupirocin or retapamulin ointment Cellulitis of unknown etiology (usually S aureus, including CA-MRSA, or group A streptococcus)1–7,19 Empiric IV therapy: Standard: oxacillin/nafcillin 150 mg/kg/day IV div q6h OR cefazolin 100 mg/kg/day IV div q8h (BII) CA-MRSA: clindamycin 30 mg/kg/day IV div q8h OR vancomycin 40 mg/kg/day IV q8h (BII) For oral therapy for MSSA: cephalexin (AII) OR amox/clav 45 mg/kg/day PO div tid (BII); for CA-MRSA: clindamycin (BII), TMP/SMX (CIII), or linezolid.

Infants and children, acute infection (usually S aureus, including CA-MRSA; group A streptococcus; K kingae) Empiric therapy: clindamycin. For serious infections, ADD cefazolin to provide better MSSA coverage and add Kingella coverage (CIII). For CA-MRSA: clindamycin 30 mg/kg/day IV div q8h or vancomycin 40 mg/kg/day IV q8h (BII) For MSSA: oxacillin/nafcillin 150 mg/kg/day IV div q6h OR cefazolin 100 mg/kg/day IV div q8h (AII) For Kingella: cefazolin 100 mg/kg/day IV div q8h OR ampicillin 150 mg/kg/day IV div q6h, OR ceftriaxone 50 mg/kg/day IV, IM q24h (BIII) Total therapy (IV plus PO) usually 4–6 wk (with end-of-therapy normal ESR, x-ray to document healing) for MSSA.

Current weight-based dosing recommendations are not intended for preterm infants. Preterm infants have more variable, slower clearance of oseltamivir because of immature renal function. Limited data suggest a dose of 2 mg/kg/day PO div bid for preterm infants. No duration investigated; follow clinically and by serial respiratory tract PCR test to determine clearing of influenza virus. 2012–2013 Nelson’s Pediatric Antimicrobial Therapy — 21 – Skin, eye, or mouth disease45–47 Condition Therapy (evidence grade) See Table 5B for Neonatal Dosages Comments Omphalitis and funisitis – Empiric therapy for omphalitis and necrotizing funisitis direct therapy against coliform bacilli, S aureus (consider MRSA), and anaerobes52–54 Cefotaxime OR gentamicin, AND clindamycin for ≥10 days (AII) Need to culture to direct therapy Alternatives for coliform coverage if resistance likely: cefepime, meropenem For suspect MRSA: add vancomycin Alternatives for combined MSSA and anaerobic coverage: pip/tazo, or ticar/clav Appropriate wound management for infected cord and necrotic tissue (AIII) – Group A or B streptococci55 Penicillin G IV for ≥7–14 days (shorter course for superficial funisitis without invasive infection) (AII) Group A streptococcus usually causes “wet cord” without pus and with minimal erythema; single dose of benazthine penicillin IM adequate Consultation with pediatric ID specialist is recommended for necrotizing fasciitis (AII).

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