By Robert Logan, Adam Harris, J. J. Misiewicz, J. H. Baron
(BMJ Books) Univ. health facility, Nottingham, united kingdom. presents a concise advisor to issues of the higher gastrointestinal tract. hugely illustrated with charts, diagrams, and colour pictures. displays most up-to-date advances in realizing the pathophysiology and pathogenesis of this ailment. For clinical scholars, nurses, and clinicians. Softcover.
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Additional resources for ABC of the Upper Gastrointestinal
5 Conclusions Currently, there is a wide range of views about what is an appropriate level of NSAID prescribing and no simple, all embracing resolution. In patients with risk factors for gastrointestinal complications the side effects of NSAIDs may outweigh all benefits. For such patients, omeprazole and misoprostol can provide effective protection, and the choice is between patients’ generally poor tolerance of misoprostol and the higher costs of omeprazole. Finally, a growing concern is the correct management of low dose aspirin used for cardiovascular protection, and no patient studies have specifically investigated this.
Bacterium In contrast, some investigators believe that H pylori is mainly responsible for disease because gastric mucosal inflammation is always present and fully resolves only when infection is successfully treated. Most strains of H pylori can be divided into two distinct phenotypes based on the presence or absence of a vacuolating toxin (Vac A toxin) and the products of the cag pathogenicity island (cagPI), a large chromosomal region that encodes virulence genes and is similar to that found in other enteric pathogens such as Escherichia coli and Salmonella typhi.
3 NSAID protection strategies x Use lowest possible doses of NSAIDs x Use safer NSAIDs Low toxicity NSAIDs COX-2 inhibitors x Use NSAID prophylaxis Proton pump inhibitors Misoprostil 1 Hawkey CJ. Non steroidal anti-inflammatory drugs and peptic ulcers: facts and figures multiply, but do they add up? BMJ 1990;300:278-84. 2 Silverstein FE, Graham DY, Senior JR, Davies HW, Struthers BJ, Bittman RM, et al. Misoprostol reduces serious gastrointestinal complications in patients with rheumatoid arthritis receiving nonsteroidal anti-inflammatory drugs.