MFV3D Book Archive > Cancer > Download Advances in DNA Repair in Cancer Therapy by Anderson T. Wang, Peter J. McHugh (auth.), Lawrence Panasci, PDF

Download Advances in DNA Repair in Cancer Therapy by Anderson T. Wang, Peter J. McHugh (auth.), Lawrence Panasci, PDF

By Anderson T. Wang, Peter J. McHugh (auth.), Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali (eds.)

​A entire overview of the hot advancements in DNA fix study that experience power for translational functions. The e-book explains intimately a number of the organic mechanisms wherein melanoma cells can dodge anticancer treatment and bounds its usefulness in sufferers. additionally they evaluation the effect of such novel inhibitors of DNA fix mechanisms as methylguanine-DNA-methyltransferase. additionally tested are inhibitors of different DNA fix enzymes corresponding to PARP and DNA-PK. The ebook captures-for either melanoma researchers and oncologists facing hallmark "relapse" or "drug resistance" phenomena on an everyday basis-the many fascinating new makes use of of DNA fix inhibitors, both by myself or together with anticancer therapies.​

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Extra resources for Advances in DNA Repair in Cancer Therapy

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Nat Struct Mol Biol 17(4):410–416 98. Walker JR, Corpina RA, Goldberg J (2001) Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412(6847):607–614 99. Zhang Z, Hu W, Cano L et al (2004) Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions. Structure 12(3):495–502 100. Harris R, Esposito D, Sankar A et al (2004) The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR). J Mol Biol 335(2):573–582 101.

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Alley MC, Hollingshead MG et al (2004) SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations. Cancer Res 64(18):6700–6706 166. Hartley JA, Hamaguchi A et al (2010) SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross-links DNA and exerts highly potent antitumor activity. Cancer Res 70(17):6849–6858 167. Hartley JA, Hamaguchi A et al (2012) DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057.

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