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Download Aldol Reactions by Rainer Mahrwald PDF

By Rainer Mahrwald

Aldol Reactions presents a finished up to date evaluate of aldol reactions together with program of other steel enolates; catalytic aldol additions catalyzed by way of diverse Lewis acids and Lewis bases; enantioselective direct aldol additions; antibodies and enzyme catalyzed aldol additions and the new competitive improvement of organocatalyzed aldol additions. the ability of every procedure is tested via numerous purposes in overall synthesis of average items. the professionals and cons of those methodologies in regards to stereoselectivity, regioselectivity and alertness in overall synthesis of ordinary items are mentioned. nice significance is determined to the varied chances of the guide of aldol response to put in required configurations in advanced typical product synthesis.

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Evans DA, Takacs JM, McGee LR, Ennis MD, Mathre DJ, Bartroli J (1981) Pure Appl Chem 53:1109 35. Evans DA (1982) Aldrichimica Acta 15:23 36. Braun M (1981) Angew Chem Int Ed Engl 26:24 37. Inoue T, Liu JF, Buske DC, Abiko A (2002) J Org Chem 67:5250 38. Fanjul S, Hulme AN, White JW (2006) Org Lett 8:4219 39. Evans DA, Sjorgren EB, Bartroli J, Dow RL (1986) Tetrahedron Lett 27:4957 40. Evans DA, Dow RL, Shih TL, Takacs JM, Zahler R (1990) J Am Chem Soc 112:5290 41. Evans DA, Weber AE (1986) J Am Chem Soc 108:6557 42.

Evans DA, Cee V, Siska SJ (2006) J Am Chem Soc 128:9433 46. (a) Goodman JM, Paton RS (2007) Chem Commun 2124; (b) Paton RS, Goodman JM (2008) J Org Chem 73:1253; (c) Paton, RS, Goodman JM (2006) Org Lett 8:4299 38 2 Aldol Reactions with Preformed Enolates 47. (a) Dias LC, Aguilar AM (2006) Org Lett 8:4629; (b) Dias LC, De Marchi AA, Ferreira MAB, Aguilar AM (2007) Org Lett 9:4869; (c) Dias LC, Aguilar AM (2008) Chem Soc Rev 37:451 48. Mori Y, Kobayashi J, Manabe K, Kobayashi S (2002) Tetrahedron 58:8263 49.

59 Elaiolide belongs to the efomycines – a class of anti-inflammatory agents isolated from microorganisms. 14). 10 Boron enolate aldol additions in total synthesis of spongistatin An efficient synthesis of epothilone D analogs has been developed using highly stereoselective boron enolate aldol addition. 61 During the total synthesis of australine a defined configured stereopentad was required. r. r. 63 The α-oxygen-containing aldehyde 71 was deployed in a convergent total synthesis of pteridic acid A.

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