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Download Apoptosis and Cancer Chemotherapy by J. Martin Brown PhD, Bradly G. Wouters PhD (auth.), John A. PDF

By J. Martin Brown PhD, Bradly G. Wouters PhD (auth.), John A. Hickman, Caroline Dive (eds.)

The earlier few years have witnessed an brilliant overseas attempt that proven the position of a few 20 new molecules in apoptosis and further activation or suppression of apoptosis to the permitted organic services of a good many others already commonly used in melanoma biology. a few of these molecules are receptors, transducing cytokine-mediated indications; others seem to accentuate or lower the chance compro­ mised telephone will fireplace its apoptosis effector mechanism. All are of curiosity as power pursuits for tumor remedy, and a few may well end up to be keep an eye on issues prompted within the pathogenesis of melanoma and different illnesses as varied as viral an infection, neurodegenerative problems, and stroke. occasionally, in the middle of those advancements, a type of euphoria ap­ pears to have gripped the study group, with the expectancy that apoptosis will find the money for reasons to many unsolved questions in cellu­ lar law. This e-book, in a sequence of considerate and provocative ar­ ticles--some from tested leaders within the box, and others from more youthful scientists--seeks to redress the balance.

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Association of p53 gene mutation with decreased chemosensitivity in human malignant gliomas. Int J Cancer 1996; 69: 236-240. 14. Li G, Tang L, Zhou X, Tron V, Ho V. Chemotherapy-induced apoptosis in melanoma cells is p53 dependent. Melanoma Res 1998; 8: 17-23. 15. Houldsworth J, Xiao H, Murty VV, Chen W, Ray B, Reuter VE, Bosl GJ, Chaganti RS. Human male germ cell tumor resistance to cisplatin is linked to TP53 gene mutation. Oncogene 1998; 16: 2345-2349. --16. , Kohn KW, et al. An information-intensive approach to the molecular pharmacology of cancer.

Oncogene 1997; 14: 2759-2766. 47. Kawashima K, Mihara K, Usuki H, Shimizu N, Namba M. Transfected mutant p53 gene increases X-ray-induced cell killing and mutation in human fibroblasts immortalized with 4-nitroquinoline I-oxide but does not induce neoplastic transformation of the cells. Int J Cancer 1995; 61: 76-79. 48. Pellegata NS, Antoniono RJ' Redpath JL, Stanbridge EJ. DNA damage and p53-mediated cell cycle arrest: a reevaluation. Proc Natl Acad Sci USA 1996; 93: 15209-15214. 49. , O'Connor PM.

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood 1993; 82: 1092-1096. Chapter 2 / p53, Apoptosis, and Chemosensitivity 35 63. Clarke AR, Gledhill S, Hooper ML, Bird CC, Wyllie AH. p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. Oncogene 1994; 9: 1767-1773. 64. Merritt AJ, Potten CS, Kemp CJ, Hickman JA, Balmain A. Lane DP, Hall PA. Role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

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