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Download Bioaccumulation - New Aspects and Developments by B. Beek PDF

By B. Beek

The bioaccumulation of endocrine disruptors, power natural chemical compounds and different compounds of excessive environmental effect has develop into of accelerating curiosity in latest environmental study, danger research and toxicology. This quantity offers an updated review and introduces the reader to the hot inspiration of "internal impact focus" linking bioaccumulation and biomagnification within the nutrients chain to ecotoxicology and probability overview.

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Examples of chemicals of antiandrogenic activity are the nonsteroidal pharmaceutical flutamide and its metabolite 2-hydroxyflutamide. The agricultural fungicides vinclozolin and procymidone with some of their metabolites, some phenylurea herbicides (PUHs), such as linuron and diuron and their metabolites 3,4-dichloroaniline and 3,4-dichloroacetanilide bind to the androgen receptor and prevent binding of natural androgens (Table 7). However, their binding affinity to the androgen receptor is relatively low compared to 5a-DHT.

Methoxychlor, nonylphenol, p,p¢-DDT, and atrazine reduced [3H]5a-DHT binding to the androgen-binding protein (ABP) by ca. 40%. Pentachlorophenol and o,p¢-DDT resulted in a significant 20% inhibition of [3H]5a-DHT binding to human sex hormone-binding globulin (hSHBG). These findings by Danzo [109] indicate that some environmental chemicals can interfere with the binding of natural hormones to two or more binding moieties, thus may be capable of disrupting physiological processes regulated by these pathways (see also Ref.

2 Chemicals with Antiestrogenic Activity (Xenoantiestrogens) In contrast to substances which exert estrogen-like activity, a variety of nonsteroidal chemicals possess antiestrogenic activity. These chemicals are also named antiestrogens or xenoantiestrogens. The term antiestrogen can be applied to several classes of chemicals that modify, modulate, inhibit, or antagonize the actions and effects of natural estrogens. g. g. androgens and progestins). In this section we will refer only to antiestrogenic compounds of groups (a) and (b).

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