By Ram I. Mahato
Newbies to the sector of biopharmaceuticals require an knowing of the fundamental rules and underlying technique taken with constructing protein- and nucleic acid-based cures for genetic and bought illnesses. Biomaterials for supply and focusing on of Proteins and Nucleic Acids introduces the foundations of polymer technology and chemistry, in addition to the fundamental biology required for figuring out how biomaterials can be utilized as drug-delivery autos. No publication so far combines a dialogue of high-tech biomaterials-based supply of protein and nucleic acid medicinal drugs with the pharmaceutical or biocompatibility points. that includes contributions from prime specialists from world wide, this article discusses physiochemical parameters used for layout, improvement, and assessment of biotechnological dosage kinds for supply of proteins, peptides, oligonucleotides, and genes. The authors additionally current organic obstacles to extravasation and mobile uptake of proteins and nucleic acids. Combining an advent to biomaterial supply with the most recent advancements within the box, it is a priceless reference for either the amateur scholar and the practising scientist on supply of biomaterials, on biomedical polymers, and on polymer therapeutics. realizing those middle basics is important to relocating directly to extra complicated research.
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Extra info for Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids
By physical or chemical cross-linking of polymer strands to form a network. A typical example of such a structure is a hydrogel. Hydrogels are threedimensional polymeric networks that swell in water but do not dissolve. Polymers can be classified based on the general composition of the monomeric components as homochain polymers and heterochain polymers. In homochain polymers the polymer chain or backbone consists of a single type of atom. Primarily this is carbon with other atoms or groups of atoms attached.
PEG is soluble in a variety of organic solvents depending on its molecular weight. The high degree of hydration and flexibility confers it as protein resistant, biocompatible, and nonimmunogenic. The PEG has been used to prolong the half-life of enzymes conjugated to the molecule thereby decreasing liver uptake. As discussed in Chapter 5, PEGs have been successfully modified at the end groups for the purpose of protein modification. The PEG conjugated adenosine deaminase (ADA), for example, has been approved by the FDA for the treatment of ADA deficiency.
2. Polymers are conventionally classified based on two major methods of synthesis namely chain polymerization and step-growth polymerization. Details of such classification and synthesis are discussed in the latter chapters of this book. ß 2005 by CRC Press The following section provides the reader with a general overview of the different types of polymers that are used primarily in biomedical applications with an emphasis on drug delivery. 1 lists the structures of commonly used polymers in drug delivery as discussed in the following sections.