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Download Bioorganic and Medicinal Chemistry of Fluorine by Jean-Pierre Bégué PDF

By Jean-Pierre Bégué

  • presents an intensive evaluation of the function of fluorine in pharmaceutical technology and improvement
  • comprises chapters on fluorinated analogues of ordinary items, fluorinated amino acids and peptides, and derivatives of sugars
  • Classifies advertised and in-development fluorinated prescription drugs in line with their healing sessions
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    Extra resources for Bioorganic and Medicinal Chemistry of Fluorine

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    Y. K. Kondratenko, Russian Chem. Rev. 1974, 43, 32. 14. T. Korenaga, K. Kadowaki, T. Ema, and T. Sakai, J. Org. Chem. 2004, 69, 7340. 15. J. A. Jamois, J. Fluorine Chem. 1991, 53, 79. 16. K. Mikami, Y. Itoh, and M. Yamanaka, in Fluorine-Containing Synthons, V. , ACE Symposium Series 911, ACS, Washington DC, 2005, p. 358. 17. A. W. Taft, F. Z. Q. S. D. M. L. M. Vlasov, R. C. Maria, J. Am. Chem. Soc. 1994, 116, 3047. J. B. Wiberg, J. Org. Chem. 1998, 63, 3937. 18. H. L. V. J. J. Taylor, J. Chem. , Perkin Trans.

    30b (90%) 29 PREPARATION OF MONOFLUORINATED COMPOUNDS Aldol reaction Condensation with imines Cycloaddition Rearrangments O F O R" O F R"X Et O Base Alkylation (Ref. 28) F "Zn" (Ref. 22) O H R' Alkylation (Ref. 29) F F O HO R HO R Dehydration R F Et R—CH N— (Refs. 28,30) O O Et R—CHO (Ref. 29) Et Br O O F Et N R OLi CH2F—COOCH2—CH CH2 Et COOEt N R H F O (Ref. 29) O F O R'X O O F Et O O Ireland–Claisen F OH (Ref. 33–36 In spite of their high toxicity, the derivatives of fluoroacetic acid are the starting molecules of many syntheses.

    2004, 69, 7340. 15. J. A. Jamois, J. Fluorine Chem. 1991, 53, 79. 16. K. Mikami, Y. Itoh, and M. Yamanaka, in Fluorine-Containing Synthons, V. , ACE Symposium Series 911, ACS, Washington DC, 2005, p. 358. 17. A. W. Taft, F. Z. Q. S. D. M. L. M. Vlasov, R. C. Maria, J. Am. Chem. Soc. 1994, 116, 3047. J. B. Wiberg, J. Org. Chem. 1998, 63, 3937. 18. H. L. V. J. J. Taylor, J. Chem. , Perkin Trans. 1990, 521. 19. K. G. E. Osterberg, Chem. Rev. 1994, 94, 373. 20. J. A. Volkmann, J. Am. Chem. Soc. 2000, 122, 466.

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