MFV3D Book Archive > International > Download Brain Edema: Proceedings of the Sixth International by I. Klatzo (auth.), Prof. Dr. Yutaka Inaba, Dr. Igor Klatzo, PDF

Download Brain Edema: Proceedings of the Sixth International by I. Klatzo (auth.), Prof. Dr. Yutaka Inaba, Dr. Igor Klatzo, PDF

By I. Klatzo (auth.), Prof. Dr. Yutaka Inaba, Dr. Igor Klatzo, Dr. Maria Spatz (eds.)

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X 27400 (Courtesy of Elsevier/ North-Holland) A morphometric study of the microvasculature of these tumours was subsequently carried out [13 a]. Sections containing the entire tumour and the surrounding brain were analysed using a digitising tablet. Blood vessel boundary (circumference), diameter and frequency, sample area and fractions occupied by viable tumour, necrosis and brain tissue were measured. In the centre of tumours vascular density decreased to 20% of the value for normal cortex, but vessel size more than doubled.

The morphology of brain tumours produced by the intracerebral injection of these cells has already been reported [5, 6]. Results and Discussion A sequential light and electron microscope study of angiogenesis revealed that on the basis of tumour vasculature three consecutive stages of tumour growth could be distinguished: avascular, early vascular and late vascular. These stages were related to the size of the tumours: the neoplasms grew to a diameter of about 1 mm during the avascular stage, after which capillary sprouts began to penetrate the tumours.

Lee JC, Bakay L (1965) Ultrastructural changes in edematous central nervous system: 1. Triethyltin edema. Arch NeuroI13:48-57 15. Marmarou A, Poll W, Shulman K, Bhagavan H (1978) A simple gravimetric technique for measurement of cerebral edema. J Neurosurg 49:530-537 16. Naruse S, Holicawa Y, Tanaka C, Hirakawa K, Nishikawa H, Yoshizaki K (1982) Proton nuclear magnetic resonance on brain edema. J Neurosurg 56:747-752 Edema Fluid and Electron Microscopic Studies in 6-ANA Brain Edema 31 17. Sasaki S (1982) Brain edema and gliopathy induced by 6-aminonicotinamide intoxication in the central nervous system of rats.

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