By Val R. Adams
A severe evaluate our present knowing of camptothecins, their shortcomings, and of the probabilities for making improvements to their medical functionality. The authors speak about new camptothecin analog improvement, drug supply concerns for optimizing their anticancer job, and their power use in numerous varied cancers. extra chapters describe what's recognized in regards to the biochemistry, the pharmacology, and the chemistry of the camptothecins, together with the mechanism of topoisomerase and the way camptothecins poison this enzyme, using animal versions in defining the anticancer power of camptothecins, and the query of camptothecin resistance.
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Additional info for Camptothecins in Cancer Therapy (Cancer Drug Discovery and Development)
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