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Download Camptothecins in Cancer Therapy (Cancer Drug Discovery and by Val R. Adams PDF

By Val R. Adams

A severe evaluate our present knowing of camptothecins, their shortcomings, and of the probabilities for making improvements to their medical functionality. The authors speak about new camptothecin analog improvement, drug supply concerns for optimizing their anticancer job, and their power use in numerous varied cancers. extra chapters describe what's recognized in regards to the biochemistry, the pharmacology, and the chemistry of the camptothecins, together with the mechanism of topoisomerase and the way camptothecins poison this enzyme, using animal versions in defining the anticancer power of camptothecins, and the query of camptothecin resistance.

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J Biol Chem 267:7806–7813. 148. Shen Z, Pardington-Purtymun PE, Comeaux JC, Moyzis RK, Chen DJ. 1996 Associations of UBE2I with RAD52, UBL1, p53, and RAD51 proteins in a yeast twohybrid system. Genomics 37:183–186. 149. Boddy MN, Howe K, Etkin LD, Solomon E, Freemont PS. 1996 PIC1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia. Oncogene 13:971–982. 150. Okura T, Gong L, Kamitani T, Wada T, Okura I, Wei CF, et al.

2000 Substitutions of Ans-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate. J Biol Chem 275:15246–15253. 20. Jaxel C, Kohn KW, Wani MC, Wall ME, Pommier Y. 1989 Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I: evidence for a specific receptor site and a relation to antitumor activity. Cancer Res 49:1465–1469. 21. Hsiang YH, Liu LF, Wall ME, et al. 1989 DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues.

3. Pourquier P, Pommier Y. 2001 Topoisomerase I-mediated DNA damage. Adv Cancer Res 80:189–216. 4. Wall ME, et al. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J Am Chem Soc 1966;88:3888–3890. 5. Hsiang YH, Hertzberg, R, Hecht S, Liu LF. 1985 Camptothecin induces proteinlinked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 260:14873–14878. Chapter 2 / Topoisomerase–DNA–Drug X-Ray Structure 37 6. Nitiss JL, Wang JC.

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