By Georges Mathé MD (auth.)
I wish to thank all my co-workers who've collaborated with me, from 1963 before, in organic and scientific study within the box of melanoma energetic immunotherapy, of its immuno prevention and immunorestoration. they are going to frequently be quoted during this e-book. i'm rather thankful to those that have helped me to write down it by means of reviewing a few chapters: D. BELPOMME, J. F. DOR~, IRENE FLORENTIN, A. GOUTNER, I. J. Hm, R. HUCHET and MARIE-CHRISTINE SIMMLER. I additionally thank NICOLE VRIZ, MARIE-CLAUDE SCHNEIDER, FENELLARIsELEY and M. JUVET for his or her keen and effective co-operation within the preperation of the manuscript. i'm ultimately thankful to all authors of books or articles who approved me to breed their figures or tables. Paris, April 1976 G. MAT~ Contents bankruptcy 1. creation and Definitions 1 bankruptcy 2. organic foundation: Tumour linked Antigens, the Immune equipment and Its Behaviour bearing on melanoma Cells five 2. 1. Tumour-Associated Antigens five 2. 2. The Immune equipment 19 2. 2. 1. Humoral Mediated Immunity and mobilephone Mediated Immunity 19 2. 2. 2. T- and B-Lymphocyte and Monocyte Differen tiation 22 2. 2. three. T-Lymphocyte services 25 2. 2. four. B-Lymphocyte services 30 2. 2. five. Macrophage services 31 2. 2. 6. K-Cell functionality 32 2. three. The Immune equipment and melanoma Cells 33 2. three. 1. Mechanisms focused on Tumour telephone Rejec tion 33 2. three. 1. 1. In vivo proof for Tumour Immunity 33 2. three. 1. 2.
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Additional info for Cancer Active Immunotherapy: Immunoprophylaxis and Immunorestoration
1 Escape Mechanisms Prior to Tumour Establishment A theory based on immune alteration in the form of immunological tolerance was much favoured at one time. Such a phenomenon has been suspected by SJOGREN (1964) in an experimental tumour system where an oncogenic virus (polyoma) was introduced into immunologically incompetent newborn hosts. , 1964). DOR£ et al. (1970b), have shown that, in AKR mice, where the RNA oncogenic virus is transmitted vertically from parents to offspring, (GROSS, 1970), a graft of isogenic ~ Fig.
46 At the present time, immunosuppression seems a more acceptable hypothesis than tolerance in explaining how the immune machinery may be incapable of eradicating the first tumour cells. , 1973; BALDWIN, 1973), X-ray irradiation (LAW and DAWE, 1960) etc. VII) for most types of cancer, (WALDMANN, 1972; GATTI and GOOD, 1971), the curve of tumour incidence rises loga- rithmically with age (Fig. 19) (Nat. Cancer Inst. VII. VII. (Continuation) Immunodeficiency Disease Number of Cases Ataxia-telangiectasia 42 Lymphosarcoma 18 Reticulosarcoma 7 Hodgkin's disease 3 Leukaemia 8 Ovarian dysgerminoma Mixed cystic glioma Cerebellar meduloblastoma Gastric adenocarcinoma 2 Basal cell carcinoma Wiskott-Aldrich syndrome Malignant reticuloendotheliosis 13 5 Lymphosarcoma, reticulosarcoma 5 Cerebellar astrocytoma Myelogenous leukaemia Leiomyosarcoma (multiple) Number (for 10QOOO inhabitants) 2500 2000 1500 1000 I ~' 10 30 / I I ,I I I 50 males - - - females I I ,I ,, I 500 I 70 90 Age Fig.
1968a). Sialic acid (Fig. 5) residues have been considered as playing an important part in antigenicity and/or immunogenicity of tumour cells. , 1966; LEE, 1968). Relations at the cell surface between malignancy, antigenicity, and immunogenicity are suggested by the action of concanavalin. This lectin is known to react with polysaccharides and glycoproteins (GOLDSTEIN and IYER, 1966), and to agglutinate many types of tumour cells, but not normal cells unless they have been pre-exposed to trypsin (INBAR and SACHS, 1969).