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Download Cancer Genomics: Molecular Classification, Prognosis and by Kenneth J. Craddock, Shirley Tam, Chang-Qi Zhu, Ming-Sound PDF

By Kenneth J. Craddock, Shirley Tam, Chang-Qi Zhu, Ming-Sound Tsao (auth.), Ulrich Pfeffer (eds.)

The mixture of molecular biology, engineering and bioinformatics has revolutionized our figuring out of melanoma revealing a decent correlation of the molecular features of the first tumor by way of gene expression, structural changes of the genome, epigenetics and mutations with its propensity to metastasize and to reply to remedy. it's not only one or a number of genes, it's the advanced alteration of the genome that determines melanoma improvement and development. destiny administration of melanoma sufferers will consequently depend on thorough molecular analyses of every unmarried case.

Through this publication, scholars, researchers and oncologists will receive a complete photo of what the 1st ten years of melanoma genomics have printed. specialists within the box describe, melanoma by way of melanoma, the growth made and its implications for prognosis, analysis and therapy of melanoma. The deep impression at the clinics and the problem for destiny translational learn develop into obtrusive.

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Bianco R, Shin I, Ritter CA, Yakes FM, Basso A, Rosen N, Tsurutani J, Dennis PA, Mills GB, Arteaga CL (2003) Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. Oncogene 22(18):2812– 2822. 1206388 51. Greulich H, Chen TH, Feng W, Janne PA, Alvarez JV, Zappaterra M, Bulmer SE, Frank DA, Hahn WC, Sellers WR, Meyerson M (2005) Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med 2(11):e313.

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