By Rodriguez-Frade J.M., Mellado M., Martinez C.
The identify CCR2 refers to 2 then again spliced chemokine receptors: CCR2A and CCR2B. even if first pointed out because the particular, high-affinity receptor for MCP-1 found in monocytic mobilephone traces, different che-mokines were proven to elicit responses via CCR2. CCR2 is expressed in monocytes, macrophages. T and В lymphocytes, ordinary killer (NK) cells, dendritic cells (DC), and in nonlymphoid cells and tissues. As one of many first chemokine receptors to be cloned and characterised, it's been studied widely. Its implication in numerous pathologies, its structure-activity dating, the signaling pathways activated, in addition to its rules were analyzed intimately and it has served as a version for the examine of alternative chemokine receptors.
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The identify CCR2 refers to 2 however spliced chemokine receptors: CCR2A and CCR2B. even supposing first pointed out because the particular, high-affinity receptor for MCP-1 found in monocytic mobilephone traces, different che-mokines were proven to elicit responses via CCR2. CCR2 is expressed in monocytes, macrophages.
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