By Jan F. C. Glatz, Joost J. F. P. Luiken, Marc van Bilsen (auth.), Jan F. C. Glatz (eds.)
It is definitely demonstrated that mobile lipid binding proteins serve primary roles in mobile lipid uptake and metabolism. facts has been offered that numerous metabolic ailments, reminiscent of hyperlipidemia, atherosclerosis, insulin resistance, and diabetes, are characterised through malfunctioning or deficiencies in mobile lipid binding proteins. For larger realizing of the motion of lipids as signaling compounds and the position of lipids in middleman metabolism, it really is necessary to have unique wisdom of the interactions among lipids and their cognant binding proteins. In view of this growing to be curiosity in lipid-protein interplay, the 4th overseas convention on Lipid Binding Proteins used to be held in Maastricht, The Netherlands, in June 2001. The court cases of the former 3 conferences were released in Molecular and mobile Biochemistry. the current concentrated factor of Molecular and mobile Biochemistry includes chosen papers in keeping with the lectures and posters provided in the course of the 4th convention, and offers perception into the importance of those proteins for the functioning of the cell.
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Extra resources for Cellular Lipid Binding Proteins
Sacchcttini JC : A pol ym o rphi sm in the hu man in te sti nal fatt y ac id bin d ing pro tein a lters fatt y ac id tr an sp ort across Caco-2 ce lls . J Bio i C hern 27 1: 10892-1 0 896 , 1996 Da ri mo nt C. G ra do ux N , Pe rsoh n E, C umin F. De Pover A : Effects of intestinal fatty ac id- bi ndi ng pr otein over expression o n fatt y aci d me tab oli sm in Caeo-2 ce lls . I Lip id Res 41 : 84-92 , 2000 Bina s B. Dann e be rg II . McW hi r J , M ullin s L. Cla rk AJ : Req uire me nt for th e heart-ty pe fatty ac id b ind ing p rot ein in cardiac fatt y ac id utilizatio n.
Knowler We. Eads J. Paoli sso G. Tataranni PA, Moch izu ki H. Benn ett PH. Boga rdus C. Prochazka M: An amino acid substitut ion in the human intestinal fatty acid bindin g protein is assoc iated with increased fatty acid bind ing. increa sed fat ox idation. and insulin resistance. I Clin Invest 95 : 1281-1 287. 1995 14. Herr I'M. Matare se V. Bernlohr DA. I: Surfac e lysine residues modul ate the collisional transfer of fatty acid from ad ipocyte tatty ac id bindin g protein to memb ranes. Biochem istry 34: 11 840 -11 845.
In order to fully define its role in lipid ass im ilation and , furth er, in wh olebod y ene rgy homeostasis. The FABPs are becom in g increa sin gl y reco gn ized for th eir potential roles in sev era l chro nic dis eas es. As men tioned abov e, the hl FABP pol ym orph ism points to an as yet ill-understood role in insulin resi stan ce and the regul atio n of pl asm a lipid levels. Th e IFABP null mou se also disp layed alterations in serum lipid s, und erscor ing th is possib ility  . The HFABP null mou se was shown to develop card iac hypertrophy, thus linking HFA BP to another common chronic disease  .