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Download COX-2 Blockade in Cancer Prevention and Therapy by Rashida A. Karmali JD PhD (auth.), Randall E. Harris MD, PhD PDF

By Rashida A. Karmali JD PhD (auth.), Randall E. Harris MD, PhD (eds.)

The discovery that aspirin and different nonsteroidal anti inflammatory medicines (NSAIDs) have remarkable antineoplastic homes has revolutionized melanoma learn. In COX-2 Blockade in melanoma Prevention and treatment, a panel of major specialists chronicles the proof for the chemopreventive and healing results of cyclooxygenase-2 (COX-2) inhibitors opposed to almost all sorts of melanoma and provides interesting new possibilities for using COX-2 blockade of their prevention and therapy. those hugely skilled authors elucidate the method during which COX-2 inhibitors interrupt prostaglandin biosynthesis and melanoma improvement, learn the optimistic epidemiological results of such NSAIDs as aspirin and ibuprofen on a variety of cancers, and exhibit via animal types that NSAIDs inhibit various malignant neoplasms in vivo. additionally they current genetic types confirming the serious position of COX-2 in carcinogenesis and talk about how its molecular biology modulates carcinogenesis through such tactics as mutagenesis, cellphone department, angiogenesis, phone differentiation, and apoptosis. furthermore, the authors assessment the medical purposes of chosen NSAIDs which are instantly correct to melanoma prevention and regulate and description the longer term customers of COX-2 blocking off agents.
entire and up to date, COX-2 Blockade in melanoma Prevention and treatment demonstrates how COX-2 inhibitors and different NSAIDs lessen the chance of cancer and gives melanoma investigators at the present time with a transparent and authoritative consultant to the improvement of novel brokers with major antineoplastic properties.

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Sample text

9. DeWitt DL, El-Harith EA, Kraemer SA, Andrews MJ, Yao EF, Armstrong RL, Smith WL. The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases. J Biol Chem 1990; 265:5192–5198. 10. Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J 1991; 5:2304–2312. 11. Takahashi Y, Ueda N, Yoshimoto T, Yamamoto S, Yokoyama C, Miyata A, et al. Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase).

Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. J Biol Chem 2000; 275:32,783–32,792. Chapter 2 / Historical Aspects of COX-2 31 63. Tanioka T, Nakatani Y, Semmyo N, Murakami M, Kudo I. Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J Biol Chem 2000; 275:32,775–32,782. 64. Xie W, Fletcher BS, Andersen RD, Herschman HR.

Surprisingly, the rat COX-2 gene does not share a CRE with the human and murine COX-2 genes. Instead, it appears that—in the rat—the E-Box may play a role in COX-2 gene regulation (67). Since the initial characterization of the cis-acting regions of the COX-2 gene that play major roles in v-src and PDGF induction were carried out, the COX-2 promoter of the human, rat, murine and chicken COX-2 genes have been subjected to an enormous number of studies; summarizing these many studies would be well beyond both the limited space and my own organizational capabilities.

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