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Download Deoxynucleoside Analogs In Cancer Therapy by Marçal Pastor-Anglada MSc, PhD (auth.), Godefridus J. Peters PDF

By Marçal Pastor-Anglada MSc, PhD (auth.), Godefridus J. Peters PhD (eds.)

Emerging as a massive new quantity within the well known melanoma Drug Discovery and improvement™ sequence, Deoxynucleoside Analogs in melanoma remedy expertly summarizes the present prestige of improvement and alertness of deoxynucleoside analogs. Authoritative updated experiences are awarded by way of scientists popular of their particular parts and all contributions comprise necessary sound suggestion on constitution and topics.
geared up into numerous sections, the 1st half covers basic features of drug uptake and metabolism and explains how novel expertise has enabled a fast enlargement of this box. the second one half is worried with a couple of particular medicinal drugs together with cytarabine, gemcitabine, troxacitabine, clofarabine and Ara-G. the ultimate part covers pharmacokinetics, prodrugs, and particular functions corresponding to radiosensitization, gene remedy, and using deoxynucleoside analogs as tracers.
all through Deoxynucleoside Analogs in melanoma remedy, the focal point is on novel points of deoxynucleoside analogs within the scientific context, in addition to on unforeseen objectives of those compounds, equivalent to their particular job opposed to cellphone cycle-dependent kinases or oncogenes. The wealth of data offered the following can be utilized to layout rational mixtures aimed toward inhibiting quite a few mobile signaling pathways, or combining inhibition of varied objectives. Deoxynucleoside Analogs in melanoma remedy has been designed particularly to facilitate such an interplay among a number of fields.

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Primary structure and functional expression of a cDNA encoding the bile canalicular purine-specific Na+-nucleoside cotransporter. J Biol Chem 1995;270:13,596–13,599. 5. Ritzel MW, Yao SY, Huang MY, Elliott JF, Cass CE, Young JD. Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1). Am J Physiol 1997;272:C707–C714. 6. Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM. Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization.

Mol Cell Biol 2004;24:2710–2719. 52. Lee CW, Sokoloski JA, Sartorelli AC, Handschumacher RE. Differentiation of HL60 cells by dimethylsulfoxide activates a Na(+)-dependent nucleoside transport system. In Vivo 1994;8:795–801. 53. Frank DA, Mahajan S, Ritz J. B lymphocytes from patients with chronic lymphocytid leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. J Clin Invest 1997;100:3140–3148. 54. Greenberg N, Schumm DE, Webb TE.

26. Zhang J, Visser F, Vickers MF, et al. Uridine binding motifs of human concentrative nucleoside transporters 1 and 3 produced in Saccharomyces cerevisiae. Mol Pharmacol 2004;64:1512–1520. 27. Vickers MF, Zhang J, Visser F, et al. Uridine recognition motifs of human equilibrative nucleoside transporters 1 and 2 produced in Saccharomyces cerevisiae. Nucleosides Nucleotides Nucleic Acids 2004;23:361–373. 28. Chang C, Swaan PW, Ngo LY, Lum PY, Patil SD, Unadkat JD. Molecular requirements of the human nucleoside transporter hCNT1, hCNT2, and hENT1.

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