By WARREN STUART
Teaches scholars to exploit the language of sythesis without delay (utilizing the grammar of synthon and disconnection) instead of translating it into that of natural chemistry.
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Introducing Carbon—and the basics of natural chemistry
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Additional info for Designing Organic Syntheses: A Programmed Introduction to the Synthon Approach
6. 6a). It was postulated that the cleavage reaction presumably occurred via a pathway similar to that in the Cope rearrangement. The iminium ion 3 would undergo [3,3]-sigmatropic rearrangement to another iminium ion (4), which upon hydrolysis produces homoallylamine and benzaldehyde. The aza-Cope rearrangement is synthetically useful because the rearrangement occurs under mild reaction conditions, and [3,3]-sigmatropic rearrangement typically proceeds with a high level of stereocontrol. 4 equiv) (97%) O O H 1.
Soc. ; Houk, K. ; Paquette, L. A. J. Am. Chem. Soc. ; Houk, K. ; Schulze, S. ; Lee, J. K. J. Org. Chem. 2003, 68 , 2310. 6. For reviews, see (a) Paquette, L. A. Tetrahedron 1997, 53 , 13971. (b) Paquette, L. A. Angew. Chem. Int. Ed. 1990, 29 , 609. 7. Boeckman, R. ; Springer, D. ; Alessi, T. R. J. Am. Chem. Soc. 1989, 111 , 8284. 8. -S. J. Am. Chem. Soc. 1990, 112 , 260. 9. Paquette, L. ; Watson, T. J. ; Freeman, B. T. J. Am. Chem. Soc. 1997, 119 , 2767. 10. ; Layton, M. ; Sheehan, S. ; Shair, M.
5 , Chap. 2; (b) Ireland, R. -N. J. Org. Chem. 1991, 56 , 3572. 3. ; Srebnick, M. Aldrichimica Acta 1993, 26, 17. 4. Ireland, R. ; Wilcox, C. S. J. Am. Chem. Soc. 1980, 102 , 1155. 5. Ireland, R. ; Anderson, R. ; Fitzsimmons, B. ; McGarvey, G. ; Wilcox, C. S. J. Am. Chem. Soc. 1983, 105 , 1988. 6. Still, W. ; Schneider, M. J. J. Am. Chem. Soc. 1977, 99 , 948. 7. (a) Grieco, P. ; Gilman, S. J. Org. Chem. 1980, 45 , 3537; (b) Martinez, G. ; Grieco, P. ; Srinivasan, C. V. J. Am. Chem. Soc. 1982, 104 , 1436.