By Robert C. Young (auth.), Robert F. Ozols M.D., Ph.D. (eds.)
Where do you start to appear for a up to date, authoritative article at the prognosis or administration of a selected malignancy? The few common oncology textbooks are normally old-fashioned. unmarried papers in really good journals are informative yet seldom accomplished; those are extra usually initial experiences on a really constrained variety of sufferers. definite basic journals usually post solid in-depth reports of melanoma subject matters, and released symposium lectures are usually the simplest overviews to be had. Unfor tunately, those reports and vitamins look sporadically, and the reader can by no means ascertain while an issue of detailed curiosity can be coated. melanoma therapy and examine is a chain of authoritative volumes that target to satisfy this want. it's an try and identify a severe mass of oncology literature masking almost all oncology issues, revised often to maintain the assurance modern, simply on hand on a unmarried library shelf or via a unmarried own subscription. we've approached the matter within the following model: first, by way of dividing the oncology literature into particular subdivisions comparable to lung can cer, genitourinary melanoma, and pediatric oncology; moment, by way of asking emi nent specialists in every one of those parts to edit a quantity at the particular subject on an annual or biannual foundation. each one subject and tumor kind is roofed in a quantity showing often and predictably, discussing present prognosis, staging, markers, all sorts of remedy modalities, simple biology, and more.
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The Palliative Care Consultations sequence is basically aimed toward these members operating in an acute health center melanoma middle and/or tertiary referral heart. Books are designed to provide the busy clinician recommendation on medical difficulties, either these infrequently encountered and those who are quite common, yet tricky.
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Extra info for Drug Resistance in Cancer Therapy
M. (1987). P-glycoprotein in human sarcoma: Evidence for multidrug resistance. 1. Clin. Oncol. 5:1452-1460. 45. , Pastan, I. M. (1987). Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug resistance gene. 1. Clin. Oncol. 5:1922-1927. 36 4. Structure and function of P-glycoprotein James H. Gerlach Combination chemotherapy was expected to solve many of the problems that had been encountered with single-agent treatment of malignant disease. The use of 'noncross-reacting' combinations would circumvent what was viewed as the limiting factor in achieving cure: the elimination of the residual, resistant (by definition) population of tumor cells.
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And Pastan, I. (1986). Increased vinblastine binding to membrane vesicles from multidrug resistant KB cells. J. BioI. Chern. 261:7921-7928. 28. Pastan, I. (1986). Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150-170 kDa protein detected by photoaffinity labeling. Proc. Natl. Acad. Sci. USA 83:3847-3850. 29. , Pastan, I. M. (1987). Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.