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Download Handbook of Metastatic Breast Cancer by Charles Swanton, Stephen Johnston, Stephen R. D. Johnston PDF

By Charles Swanton, Stephen Johnston, Stephen R. D. Johnston

There was once constrained healing innovations for ladies who built metastatic breast melanoma. even if, fresh improvement with novel systemic medicines and palliative surgical ideas, including advances in diagnostic imaging, have given new desire for those sufferers and made the therapy of those sufferers significantly more difficult. One handy resource bringing jointly a few of the proper points is lengthy late. This guide covers remedy for either the melanoma and the issues that may come up from therapy itself.

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Qxd 6/30/2006 2:34 PM Page 35 Chemotherapy and metastatic breast cancer 35 The goals of chemotherapy treatment continue to remain the same for all patients with metastatic breast cancer: namely, minimising toxicity of treatment and hospital admissions while maximising symptom improvement, quality of life and survival. Following use of first-line chemotherapy for metastatic breast cancer, at subsequent disease progression, different cytotoxic drugs or combinations may be used. However, further use of sequential chemotherapy needs careful consideration in relation to likelihood of benefit versus risk of toxicity and deteriorating performance status.

Many patients with metastatic breast cancer are over the age of 65 and may present with life-threatening disease requiring chemotherapy. Elderly patients may be at increased risk of myelosuppression induced by cytotoxic agents, and co-morbidity as well as drug history should be considered when choosing the appropriate regimen. Thus, agents with lower toxicity may often be considered as preferable for this patient group. 6 However, a disease-free interval of less than 12 months prior to adjuvant treatment implies a degree of resistance to the previous regimen and will influence the choice of first-line chemotherapy for metastatic breast cancer.

Drugs Aging 1998; 13: 321–32. 7. Lonning PE. Pharmacological profiles of exemestane and formestane, steroidal aromatase inhibitors used for treatment of postmenopausal breast cancer. Breast Cancer Res Treat 1998; 49 (Suppl 1): S45–52, discussion S73–7. 8. Buzdar A, Jonat W, Howell A, et al. Anastrozole, a potent and selective aromatase inhibitor, versus megestrol acetate in postmenopausal women with advanced breast cancer: results of overview analysis of two phase III trials. Arimidex Study Group.

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