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Download Lymphocytes in Immunotherapy of Cancer by R. B. Herberman (auth.), Dr. Paul Koldovsky, Dr. Ursula PDF

By R. B. Herberman (auth.), Dr. Paul Koldovsky, Dr. Ursula Koldovsky, Dr. Lutwin Beck, Dr. Karl-Heinz Vosteen (eds.)

In the earlier, learn in melanoma immunology has produced informa­ tion vital for different scientific disciplines. It helped, for instance, in formulating the legislation of immunogenetics and in attaining a greater figuring out of the mechanism governing the destiny of allotrans­ planted tissue. melanoma has frequently been thought of a overseas physique, and for this reason many makes an attempt were made to remedy it at the foundation of the immunological ideas acceptable to parasitic, bacterial, or viral illnesses. Vaccination has been investigated clinically for its po­ tential to avoid melanoma [1], and medical study into the treatment of melanoma has integrated energetic immunization [2], nonspecific stimulation of protection mechanisms [3], and move of passive immunity by means of cells [4] or through antibodies [5]. those experiments were of restricted worth and often times have even had an opposed impact. The popularity of melanoma immunology has suffered, and the concept that has frequently been significantly criticized. notwithstanding, the elemental postulate that melanoma needs to originate from the body's personal cells, and that the immune method belongs to the valuable regulatory mechanisms, is still legitimate. in recent times new examine into scientific melanoma immunotherapy has incorporated serious appraisal of all its strength merits, and likewise of the dangers and boundaries. it's risky to make unrealistic offers or to talk or imagine when it comes to "miracle guns" or a "magic bul­ let.

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Sample text

Shiba et al. [15] also described a positive effect on LAK induction of addition of y-IFN predominantly in cancer patients. Ochoa et al. [9] found an excellent increase of LAK activity and of the numbers of lytic cells by activation of the T cell receptor with anti-CD3 (OKT3) in long-term cultures. Despite a moderate increase of cell numbers in long-term cultures (14-21 days, data not shown), we could not confirm the approximately lOOO-fold expansion of cell numbers in cultures with IL-2 and anti-CD3.

Is the clinical and immunological status of the patient suitable for immuno- therapy? 2. Will the stimulated lymphocytes not cause severe side effects? 46 P. and U. Koldovsky 3. Will they inhibit tumor growth effectively, or does a potential danger of tumor growth promotion exist? Several laboratory methods are used to answer these questions. Let us discuss those used in our laboratory. For any immune-related disease the absolute count of peripheral blood mononuclear cells (PBMC) and the relative size of the subpopulations will give some information.

Numerous interesting approaches and promising results in individual cases were described. Hard evidence, however, was lacking. The research was dominated by the concept, very fruitful from the immunogenetic point of view, that patient and tumor are two more or less separate il1dividuals [2]. The tumor can certainly be considered as a parasite [3]. Indeed tumor immunology can profit from comparison with the immunopathology of parasitic diseases. The main goal of tumor immunology was to find and isolate tumor-specific transplantation antigens and to eventually produce a vaccine or an effective antiserum [4].

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