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Download Mechanisms of Drug Resistance in Neoplastic Cells. by Paul V. Woolley PDF

By Paul V. Woolley

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Read Online or Download Mechanisms of Drug Resistance in Neoplastic Cells. Bristol–Myers Cancer Symposia, Volume 9 PDF

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Additional info for Mechanisms of Drug Resistance in Neoplastic Cells. Bristol–Myers Cancer Symposia, Volume 9

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MATHEMATICAL MODELING OF DRUG RESISTANCE 27 neoplasms are treated with programs of cytotoxic agents. Moreover, as the modeling becomes more sophisticated, it offers hope that it will be of direct value in prospectively planning new chemotherapy protocols that will be less empirical and more effective in accomplishing their goals of curing disseminated cancer. References 1. G. H. Heppner, Tumor heterogeniety. Cancer Res. 2259-2265 (1984). 2. D. L. Dexter and J. T. Leith, Tumor heterogeneity and drug resistance.

1, but actually between 12 and 24 hr later (100 times that of control cells). The enhanced frequency decays progressively when cells are plated into MTX at 48 and 72 hr. We have made similar observa­ tions with hydroxurea (Brown et al, 1983) and UV light (Tlsty et al, 1984) enhancement of MTX resistance. Thus, we conclude that the enhanced resistance requires DNA synthesis and that there is an optimal time for demonstrating MTX resistance. The reasons for the decline in frequency following inhibition of DNA synthesis are complex and not fully understood.

A randomized study of this approach compared to using the MOPP protocol has not been carried out, nor would it be ethically permissible at this time. Nonetheless, this sequential application of agents corresponds roughly to what was the treatment of Hodgkin's disease in the early 1960s before the MOPP protocol was developed. We know from experience at that time that this sequential application of active agents almost never resulted in cure, though it did result in a series of remissions of varying duration.

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