MFV3D Book Archive > Cancer > Download Metal Compounds in Cancer Therapy by Simon P. Fricker (auth.), Simon P. Fricker (eds.) PDF

Download Metal Compounds in Cancer Therapy by Simon P. Fricker (auth.), Simon P. Fricker (eds.) PDF

By Simon P. Fricker (auth.), Simon P. Fricker (eds.)

The discovery of the antitumour job of cisplatin in 1965 and its next advent into medical trials in 1971 used to be the catalyst for a huge overseas learn attempt investigating the possibility of steel compounds in melanoma treatment. Cisplatin now occupies a massive position within the armamentarium of the oncologist because of its effectiveness within the therapy of testicular melanoma. A moment new release analogue, carbo­ platin, deals decreased toxicity including healing task, which provides it a spot within the front-line treatment of genitourinary cancers. those and different successes have inspired the hunt for novel metal-based medicines for melanoma remedy. examine has proven that steel compounds have strength for task not just as cytotoxic antitumour brokers, but additionally in parts resembling adjuvant remedy, prognosis and immunotherapy. the purpose of this e-book is to study and describe the foremost achievements and advancements bobbing up from this overseas study attempt. The contributing authors come from labora­ tories all through Europe and the US and symbolize the numerous disci­ plines attribute of this study, comparable to scientific learn, pharmacology, tumour biology and inorganic medicinal chemistry.

Show description

Read Online or Download Metal Compounds in Cancer Therapy PDF

Best cancer books

Palliative Care Consultations in Advanced Breast Cancer (Palliative Care Consultations)

The Palliative Care Consultations sequence is essentially geared toward these contributors operating in an acute medical institution melanoma heart and/or tertiary referral heart. Books are designed to offer the busy clinician suggestion on medical difficulties, either these hardly encountered and those who are quite common, yet tough.

The Official Patient's Sourcebook on Prostatitis: A Revised and Updated Directory for the Internet Age

This e-book has been created for sufferers who've determined to make schooling and examine an essential component of the therapy approach. even though it additionally offers details precious to medical professionals, caregivers and different wellbeing and fitness pros, it tells sufferers the place and the way to appear for info protecting almost all issues regarding prostatitis (also continual bacterial prostatitis; Pelvic discomfort syndrome; Prostate an infection (Inflammatory); Prostatodynia), from the necessities to the main complicated components of analysis.

Cancer Detection: Prepared by the Cancer Detection Committee of the Commission on Cancer Control

The 1st variation of this Monograph on melanoma Detection used to be released by way of the Inter­ nationwide Union opposed to melanoma (U. I. CC) in 1966. due to the fact that that point the Committee respon­ sible for that Monograph has won enormous adventure during the association of a cervical screening programme in Santiago, Chile and a symposium at the review of mass screening programmes in Sheffield, England.

Cancer Epidemiology Among Asian Americans

Melanoma Epidemiology in Asian americans is a accomplished quantity that offers the most up-tp-date learn on melanoma etiology inside of this speedy becoming inhabitants sub-group within the usa. The publication explores epidemiologic tools which are quite often utilized in migrant reviews, delivering descriptive epidemiology of melanoma styles individually in chinese language, eastern, Filipino and different Asian ethnic teams together with Asian Indians, Koreans, Vietnamese, and different Southeast Asians.

Additional info for Metal Compounds in Cancer Therapy

Example text

The NCI calculate three parameters, defined as GI so , TGI and LC so, where percentage growth is + 50,0 and - 50 respectively. This is achieved by using a high starting cell number in the assay so that biomass reduction (LCso) can be measured. These three figures are calculated for each cell line for each test compound. Mean graphs are then constructed in which the mean GIso, TGI and LC so are calculated from all the cell lines for a given compound and the log difference of the individual values from the mean plotted as a bar chart.

1991) Growth factor and oncogene signalling pathways as targets for rational anticancer drug development. Clin. , 24, 385-397. Pyle, A. M. and Barton, J. K. (1990) Probing nucleic acids with transition metal complexes, in Progress in Inorganic Chemistry: Bioinorganic Chemistry, Vol. 38 (ed. S. J. Lippard), John Wiley and Sons, New York, pp. 413-75. Reich, R, Thompson, E. , Iwamoto, Y. eta!. (1988) Effects of inhibitors of plasminogen activator, serine proteases and collagenase IV on the invasion of basement membranes by metastatic cells.

19, 243-310. Kopf-Maier, P. and Kopf, H. (1987) Non-platinum-group metal antitumor agents: history, current status, and perspectives. Chem. , 87, 1137-52. 30 Introduction Korbelik, M. (1991) Photosensitizers in photodynamic therapy. Periodicum Biologorum, 93(4), 563-74. Lempers, E. L. M. and Reedijk, J. (1991) Interactions of platinum amine compounds with sulfur-containing biomolecules and DNA fragments. Adv. Inorg. , 37, 175-217. Lerea, K. , Krebs, E. G. etal. (1989) Vanadate and molybdate increase tyrosine phosphorylation in a 50-kilodalton protein and stimulate secretion in electropermeabilized platelets.

Download PDF sample

Rated 4.25 of 5 – based on 28 votes