By Robert E. Mansel MS, FRCS, CBE, Oystein Fodstad PhD (auth.), Robert E. Mansel MS, FRCS, CBE, Oystein Fodstad PhD, Wen G. Jiang MB, BCh, MD (eds.)
Metastasis (spread of melanoma within the physique) is the most reason behind demise for sufferers with breast melanoma, the best lady tumour within the industrialised international locations and constructing nations alike. The biology and remedy of breast melanoma metastasis is still an energetic quarter of clinical and scientific investigation.
Written by means of specialists within the topic sector, the e-book has coated a large diversity of subject matters within the metastasis of breast melanoma, from genetics, biology to scientific administration. major subject matters contain genetic keep watch over, biology, progress elements, mobile adhesion, cellphone motility and invasion, natures of bone metastasis, sentinel node cures, hormonal hyperlinks, new biomarkers and detection of micrometastasis, and analysis The e-book additionally covers the present treatment plans together with surgical administration, chemotherapy and hormonal treatments. This well timed booklet presents the present wisdom within the sector of breast melanoma metastasis and may be of vital examining fabric for oncologists, radiologists, melanoma researchers, biologists and healthiness worker.
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Extra info for Metastasis of Breast Cancer
113. 114. 115. Samant, Fodstad, and Shevde Seraj MJ, Samant RS, Verderame MF, Welch DR. Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. Cancer Res 2000, 60(11):2764–2769. Samant RS, Seraj MJ, Saunders MM, Sakamaki TS, Shevde LA, Harms JF, Leonard TO, Goldberg SF, Budgeon L, Meehan WJ et al. Analysis of mechanisms underlying BRMS1 suppression of metastasis. Clin Exp Metastasis 2000, 18(8):683–693. Samant RS, Debies MT, Shevde LA, Verderame MF, Welch DR.
In contrast, KAI1 expression was reduced in most of the infiltrating breast tumors. More malignant tumors demonstrated significantly lower KAI1 expression (112). 5. MKK4 MKK4, located in close proximity to p53 gene, is thought to be a tumor and a MSG. A low-rate MKK4 gene alteration has been found in a few tumor types, including breast and pancreatic cancers (113). Also, the expression of MKK4 is significantly reduced in breast cancer brain metastases (109). A suppressor activity for prostate and ovarian tumor metastasis has also been suggested (114) (115).
KiSS-1 expression in human breast cancer. Clin Exp Metastasis 2005, 22(6):503–511. Arnaud-Dabernat S, Bourbon PM, Dierich A, Le Meur M, Daniel JY. Knockout mice as model systems for studying nm23/NDP kinase gene functions. Application to the nm23-M1 gene. J Bioenerg Biomembr 2003, 35(1):19–30. Yang X, Wei L, Tang C, Slack R, Montgomery E, Lippman M. KAI1 protein is down-regulated during the progression of human breast cancer. Clin Cancer Res 2000, 6(9):3424–3429. Su GH, Hilgers W, Shekher MC, Tang DJ, Yeo CJ, Hruban RH, Kern SE.