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Download Modulating Gene Expression by Antisense Oligonucleotides to by Margaret M. McCarthy (auth.), Margaret M. McCarthy (eds.) PDF

By Margaret M. McCarthy (auth.), Margaret M. McCarthy (eds.)

When first brought, antisense oligonucleotides have been hailed because the lengthy awaited magic bullet that will offer an exceptional point of specificity in controlling gene expression. Following this preliminary enthusiasm, antisense oligonucleotides were maligned as nonspecific, poisonous, and basically lifeless. despite the fact that, software of antisense oligonucleotide know-how within the fearful approach stands except using this system in peripheral platforms, mostly due to its huge, immense good fortune. The resource of this good fortune continues to be an issue of a few controversy.
Modulating Gene Expression by way of Antisense Oligonucleotides to UnderstandNeural Functioning addresses the origins of that controversy and determines no matter if the fearful procedure is a privileged web site for antisense oligonucleotide motion and never topic to an identical vagaries and pitfalls as non-neuronal structures.
Modulating Gene Expression via Antisense Oligonucleotides to UnderstandNeural Functioning comprises chapters via specialists within the box that concentrate on using this method in a number of behavioral structures, in addition to quick and nonspecific results and the uptake and metabolism of antisense oligonucleotides through the worried approach.
Modulating Gene Expression through Antisense Oligonucleotides to UnderstandNeural Functioning beneficial properties:

  • experts within the box reporting at the use of antisense oligonucleotide expertise in a number of behavioral structures, together with discomfort keep an eye on, circadian rhythms, ingestion and regulate of water stability, and reproductive behaviors;
  • the novel use of plasmids to specific antisense RNA within the frightened procedure;
  • the biodistribution and metabolism of antisense oligonucleotides within the fearful method;
  • rapid and strange results; and
  • non-specific effects.

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Additional info for Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning

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Mol Brain Res 1994;21:55-61 Akhtar S and Juliano RL. Liposome delivery of antisense oligonucleotides - adsorption and efflux characteristics of phosphorothioate oligodeoxynucleotides. J Control Release 1992;22:47-56 Akhtar S, Ko1e R, Juliano RL. Stability of antisense DNA oligodeoxynucleotide analogs in cellular extracts and sera. Life Sci 1991;49:1793-1801 Akhtar S, Shoji Y, Juliano RL. Pharmaceutical aspects of the biological stability and membrane transport characteristics of antisense oligonucleotides.

0 c +-' C (l) 0. 40 30 (f) (l) E 20 +-' "D c 10 ID (f) (l) L- +-' c 0 Entries Time Entries Time W Figure 5. 0 I1g of missense phosphorothioate ODN. Two independent groups of animals (n=8 per group) were tested 2 and 5 hr after the injection of vehicle (open bar) or ODN (solid bar), respectively. The figure shows the number of entries into the open arms of the maze, expressed as the percentage of the total number of entries into both types of arms, and the mean time the animals spent in the open arms, expressed as the percentage of the total time in the maze.

Trends Biotechnol 1996;14:147-152 Stein CA and Cheng YC. Antisense oligonucleotides as therapeutic agents - is the bullet really magical? Science 1993;261:1004-1012 Toulme JI, Bourget C, Compagno D, Yurchenko L. Control of gene expression in viruses and protozoan parasites by antisense oligonucleotides. Parasitology 1997; 114 Suppl:45-59 Wahlestedt C. Antisense oligonucleotide strategies in neuropharmacology. Trends Pharmacol Sci 1994;15:42-46 Webb A, Cunningham D, Cotter F, Clarke PA, Distefano F, Ross P, Corbo M, Dziewanowska Z.

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