By Angelika M. Burger, Arun K. Seth (auth.), Eric Rubin, Kathleen Sakamoto (eds.)
This booklet comprises chapters written by means of specialists within the box of the ubiquitin proteasome method and melanoma. The authors have summarized present info on ubiquitin ligases and proteasomes as strength pursuits for melanoma treatment. subject matters lined within the e-book contain an outline of ubiquitin ligases, deubiquitinating enzymes, and the proteasome. particular ailments due to deregulated ubiquitin ligases, equivalent to Von-Hippel-Lindau disorder and Fanconi anemia also are mentioned. ultimately, novel ways and medicine to focus on proteins interested in sumoylation, ubiquitination, and degradation are described.
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Additional resources for Modulation of Protein Stability in Cancer Therapy
The ubiquitin system. Annu Rev Biochem 67, 425–479. , and Harris, C. C. (1991). p53 mutations in human cancers. Science 253, 49–53. Holowaty, M. , and Frappier, L. (2003). Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7. J Biol Chem 278, 29987–29994. , Kim, S. , and Kang, S. (2002). USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product. Mol Cell Neurosci 20, 298–306.
2005). HAUSP, a deubiquitinating enzyme for p53, is polyubiquitinated, polyneddylated, and dimerized. FEBS Lett 579, 4867–4872. , Maurice, M. , Teunisse, A. , Abraham, T. , Dirks, R. , and Jochemsen, A. G. (2005). Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2. Mol Cell 18, 565–576. Millard, S. , and Wood, S. A. (2006). Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes. J Cell Biol 173, 463–468. , Wagner, D.
2006). Drosophila USP7 has been shown to interact with guanosine 5-monophosphate synthetase (GMPS) and together mediate the deubiquitination of histone H2B (van der Knaap et al. 2005). This deubiquitination event is important for the epigenetic silencing of homeotic genes mediated by the Polycomb protein (Pc). HAUSP also deubiquitinates mammalian FOXO4 in response to oxidative stress and negatively regulates its transcriptional activity. In addition, HAUSP interacts with the neuronal protein Ataxin-1, an SCA1 gene product implicated in the neurodegenerative disorder spinocerebellar Ataxia Type-1, though the implications of this interaction remain to be seen.