MFV3D Book Archive > Cancer > Download New Drugs, Concepts and Results in Cancer Chemotherapy by John S. Holcenberg, Henry P. Wu (auth.), F. M. Muggia (eds.) PDF

Download New Drugs, Concepts and Results in Cancer Chemotherapy by John S. Holcenberg, Henry P. Wu (auth.), F. M. Muggia (eds.) PDF

By John S. Holcenberg, Henry P. Wu (auth.), F. M. Muggia (eds.)

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Dipyridamole has been found to increase the cytotoxicity of SFU in the human colon carcinoma HCT 116 cell line [S,41-43], human epidermoid carcinoma Hep-2 and human breast cancer MCF-7 lines [37], and (when combined with the uridine phosphyrylase inhibitor, benzylacyclouridine) human colon carcinoma CT38 cell line [44]. This modulation was dose and time dependent [S,41-43]. For example, the cell number after a 72-hour exposure to S 11M SFU and S 11M dipyridamole was 22% of that seen with SFU alone.

Augmentation of 5-fluorouracil cytotoxicity in human colon cancer cells by dipyridamole. Cancer Res 45:2967-2972, 1985. 42 42. Grem JL and Fischer PH.

18 2. Modulation of the activity of cancer chemotherapeutic agents by dipyridamole Rakesh Goel and Stephen B. Howell Introduction Dipyridamole (2, 6,-bis- diethanolamino-4, 8-dipiperidinopyrimido-5, 4-dpyrimidine) is a pyrimidopyrimidine derivative (illustrated in figure 1) that is commonly prescribed as a coronory vasodilator for the long-term therapy of angina pectoris, as an antiplatelet drug in various thrombotic disorders, such as coronory and cerebrovascular disease [1,2]. However, only its therapeutic use in combination with coumarin anticoagulants to reduce the risk of postoperative thromboembolic complications in patients undergoing cardiac valve replacement is approved by the Food and Drug Administration [3].

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