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Download Non-coding RNAs and Cancer by Muller Fabbri MD, Ph.D. (auth.), Muller Fabbri (eds.) PDF

By Muller Fabbri MD, Ph.D. (auth.), Muller Fabbri (eds.)

The discovery of microRNAs and its function as gene expression regulators in human carcinogenesis represents essentially the most very important clinical achievements of the decade. extra lately, different non-coding RNAs were stumbled on and its implications in melanoma are rising to boot, suggesting a broader than expected involvement of the non-coding genome in melanoma. in addition, thoroughly new and unforeseen features for microRNAs are being published, resulting in the identity of latest anticancer molecular objectives. This booklet represents a complete advisor on non-coding RNAs and melanoma, spanning from its function as melanoma biomarkers, to delivering the main priceless bioinformatic instruments, to offering the most proper discoveries, which shows how those interesting molecules act as high-quality orchestrators of melanoma biology.

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Pang KC, Stephen S, Dinger ME, Engstrom PG, Lenhard B, Mattick JS. 0–an expanded database of mammalian non-coding RNAs. Nucleic Acids Res. 2007;35:D178–82. 16. Pruitt KD, Tatusova T, Maglott DR. NCBI reference sequences (RefSeq): a curated nonredundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res. 2007;35:D61–5. 17. Kapranov P, Willingham AT, Gingeras TR. Genome-wide transcription and the implications for genomic organization. Nat Rev Genet. 2007;8:413–23. 18. Birney E, Stamatoyannopoulos JA, Dutta A, Guigo R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, et al.

Keywords microRNA • LncRNA • Real-time PCR • Microarrays • Next-generation sequencing C. Perdomo (*) • J. edu F. Schembri Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA M. 1 C. Perdomo et al. Introduction There are many different technologies currently available for ncRNA detection which are essentially reflective of, and adapted from, those used to measure coding RNAs. Traditional older methods of RNA detection and quantification such as in situ hybridization [1] and northern blot [2] are indeed applicable to noncoding species, both large and small; however, this chapter focuses on more modern and higher throughput methods.

J Pathol. 2010;221(2):139–46. 139. Heravi-Moussavi A et al. Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers. N Engl J Med. 2012;366(3):234–42. 140. Kumar MS et al. Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev. 2009;23(23):2700–4. 141. Pasquinelli AE et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000;408(6808):86–9. Chapter 3 Detecting Noncoding RNA Expression: From Arrays to Next-Generation Sequencing Catalina Perdomo, Joshua Campbell, and Frank Schembri Abstract Detection and quantification of noncoding(nc) RNA species can present specific challenges as compared to mRNA.

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