By Lesley G. Ellies Ph.D., Andrew Johnson (auth.), Andrew J. Dannenberg, Nathan A. Berger (eds.)
In addition to its metabolic and endocrinologic results, weight problems and adipose tissue have now been proven to be linked to low grade irritation leading to mobile and humoral inflammatory elements of which the latter could act through endocrine, paracrine and autocrine mechanisms. those inflammatory mediators have more and more been instructed as contributing to the weight problems hyperlink to carcinogenesis and melanoma promoting.
This quantity of strength stability and melanoma will specialize in fresh advancements and leading edge study pointing to irritation and inflammatory components as key mediators of this linkage. the amount first presents details on irritation as an incredible hyperlink among weight problems and insulin resistance, that's in itself associated with advertising of melanoma via hyperinsulinemia. the quantity then covers essentially the most very important mechanisms during which weight problems results in irritation, together with the unconventional inflammasome inspiration, changes in chromatin constitution, circulating inflammatory components, targeted mobile interactions among adipocytes and macrophages and the direct hyperlink of nutritional fats to irritation and melanoma.
Overall, this quantity will supply very important perception to aid know the way irritation can assist modulate the linkage among weight problems and melanoma and function a platform for constructing destiny examine during this area.
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Additional info for Obesity, Inflammation and Cancer
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Hsueh Abstract Inflammasomes are a family of protein complexes that recognize diverse microbial and endogenous danger signals to promote innate immune responses, tissue inflammation and injury, or cell death via pyroptosis. Inflammasome activation results in the recruitment and activation of caspase-1, which is required for the production of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 that can modulate both adaptive and innate immune responses through effects on leukocyte survival, proliferation, differentiation, and migration.
A. 1007/978-1-4614-6819-6_2, © Springer Science+Business Media New York 2013 25 26 T. Deng et al. conditions. This chapter will review new research on inflammasome activation, its role in obesity and other chronic inflammatory states, and the status of approaches to attenuate NLRP3 inflammasome activity. 1 Inflammasomes Are Key Mediators of the Innate Immune System The innate immune system serves as a first line of defense against invading microbes and other harmful agents by sensing pathogen-associated molecular patterns (PAMPs), such as microbial nucleic acid, lipoproteins, and lipopolysaccharides (LPSs), or danger-associated molecular patterns (DAMPs) released during cell stress, including ATP, uric acid, heat shock proteins, and other cellular components .