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Download Options in the treatment of head and neck cancer by MD Marshall R. Posner PDF

By MD Marshall R. Posner

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Extra resources for Options in the treatment of head and neck cancer

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More than 70% of patients had T4 cancers, and more than 70% had N2 or N3 nodal disease. More than 300 patients were entered on this study. The majority of cancers arose in the oropharynx. Survival was significantly better with TPF compared to PF. At 3 years, 37% of the TPF patients were alive compared to 24% of the PF patients. Overall, there was a 29% reduction in mortality with TPF compared to PF in this unresectable population. Also noteworthy, mucositis in the TPF arm was less than that obtained in the PF arm, and treatment-related mortality was reduced by 50%.

J Clin Oncol 1998;16(4):1310–1317. 13. Calais G, Alfonsi M, Bardet E, et al. Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. J Natl Cancer Inst 1999;91(24):2081–2086. 14. Denis F, Garaud P, Bardet E, et al. Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma. J Clin Oncol 2004;22(1):69–76.

90%), and there was less toxicity-related mortality in the TPF arm. bk Page 32 Friday, October 20, 2006 11:41 AM 32 Evolving Role of Induction Chemotherapy Recently, Calais et al. (29) presented the results of a phase III organ preservation trial performed by the GORTEC in patients with larynx and hypopharynx cancer comparing TPF to PF. These patients were treated with three cycles of TP or PF, and then responders received radiotherapy and nonresponders underwent laryngectomy. All patients have finished therapy, and follow-up is ongoing.

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