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Download Organolithiums in Enantioselective Synthesis by David M. Hodgson PDF

By David M. Hodgson

Content material: Arsenic-based medicines : From Fowler's option to glossy anticancer chemotherapy / Stéphan Gilbaud and Gérard Jaouen -- Activation mechanisms for organometallic anticancer complexes / Ana M. Pizarro, Abraha Habtemariam, and Peter J. Sadler -- Organometallic antitumour brokers with replacement modes of motion / Angela Casini ... [et al.] -- Ferrocene functionalized endocrine modulators as anticancer brokers / Elizabeth A. Hillard, Anne Vessieres, and Gerard Jaouen -- Titanocenes : Cytotoxic and anti-angiogenic chemotherapy opposed to complex renal-cell melanoma / Megan Hogan and Matthias Tacke -- Organometallics as structural scaffolds for enzyme inhibitor layout / Seann P. Mulcahy and Eric Meggers -- Bioorganometallic chemistry and malaria / Christophe Biot and Daniel Dive -- Biomedical functions of organometal-peptide conjugates / Nils Metzler-Nolte -- Organometallic radiopharmaceuticals / Roger Alberto -- Carbon-monoxide : a necessary signaling molecule / Brian E. Mann

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Extra resources for Organolithiums in Enantioselective Synthesis

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5% ee [16]. References 1. In this review, the optical purities are reported uncorrected as presented in the original publications 2. Corey EJ, Cheng XM (1995) The logic of chemical synthesis. Wiley, New York 3. Huryn DM (1991) In: Trost BM, Fleming I (eds), Comprehensive organic synthesis. Pergamon Press, Oxford, p 49 4. Sapse A-M, Schleyer, P v R (eds) (1995) Lithium chemistry. Wiley, New York 5. Lambert C, Schleyer P v R (1994) Angew Chem 106: 1187; Angew Chem Int Ed Engl 33:1129 6. Lambert C; Schleyer P v R (1993) In: Methoden org chem (Houben Weyl).

The N-aryl substitution in the starting imines exerts a profound effect on enantioselectivities. Particularly in the case of addition to the imines bearing substituted N-4-methoxyphenyl or N-naphthyl groups 77, excellent enantioselectivities (up to 97% ee) were obtained (Scheme 23) [71]. Reaction of heterocycle-involving imine and heterocyclic carbonucleophiles in the presence of a chiral ligand has been also reported [72, 73]. Scheme 23. The synthetic utility of the enantioselective addition to an azomethine function relies on a practical method for the N-dearylation of the resulting chiral amines.

Preparation by Reductive Lithiation . . . . . . . . . Preparation by Stereospecific Deprotonation . . . . . . Preparation by Diastereoselective Deprotonation . . . . .

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